In immuno-suppressed people, such as transplant patients, parainfluenza virus infections can cause severe pneumonia, which is often fatal.
Human parainfluenza viruses
From Wikipedia, the free encyclopedia
Human parainfluenza viruses (HPIVs) are a group of four distinct serotypesof single-stranded RNA viruses belonging to the paramyxovirus family.
Parainfluenza viruses can be detected via cell culture, immunofluorescentmicroscopy, and PCR.
They are the second most common cause of lower respiratory tract infection in younger children. Together, the parainfluenza viruses cause ~75% of the cases of Croup.
Repeated infection throughout the life of the host is not uncommon. Symptoms of later breakouts include upper respiratory tractillness as in a cold and sore throat. The incubation period of all four serotypes is 1 to 7 days. In immunosuppressed people, such as transplant patients, parainfluenza virus infections can cause severepneumonia, which is often fatal.
Parainfluenza viruses last only a few hours in the environment and are inactivated by soap and water.
There are four serotypes. These include:
- HPIV-1 (most common cause of croup; also other upper and lower respiratory tract illnesses typical)
- HPIV-2 (causes croup and other upper and lower respiratory tract illnesses)
- HPIV-3 (associated with bronchiolitis and pneumonia)
- HPIV-4 (includes subtypes 4a and 4b)
- ^ Vainionpää R, Hyypiä T (April 1994). “Biology of parainfluenza viruses“. Clin. Microbiol. Rev. 7 (2): 265–75. PMID 8055470.PMC 358320.
- ^ Sable CA, Hayden FG (December 1995). “Orthomyxoviral and paramyxoviral infections in transplant patients”. Infect. Dis. Clin. North Am. 9 (4): 987–1003. PMID 8747776.
- ^ Sato M, Wright PF (October 2008). “Current status of vaccines for parainfluenza virus infections“. Pediatr. Infect. Dis. J. 27(10 Suppl): S123–5. doi:10.1097/INF.0b013e318168b76f. PMID 18820572.
- ^ “CDC – Human Parainfluenza Viruses: Common cold and croup“. Retrieved 2009-03-15.
^ “Parainfluenza Viruses“. Retrieved 2009-03-15.
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